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The explosion and fire were reported just after 2:30 p.m., according to a dispatcher. Firefighters are battling a fire in the roof and attic.
After reports of a natural gas leak that led to an explosion, more than a dozen fire units and utility crews were on scene at the Kelton House Museum and Garden in Columbus around 2:30 pm on Monday.
Columbus Fire has not yet released any details about the extent of the damage or whether anyone has been hurt.
19hon MSN
Harvard Medical School explosion suspects on the run, police say it's safe to return to campus
Two masked suspects remain at large after Saturday's explosion at Harvard Medical School's Goldenson Building. Police have since said it was safe to return to campus.
2don MSN
Video shows propane tank explosion in Delaware damaging buildings, homes near railroad tracks
Video shows a propane tank explosion in Bear, Delaware, that damaged several nearby buildings and homes, officials said.
The Federal Bureau of Investigation is assisting Boston and Harvard authorities in the investigation of an 'intentional' explosion at the university.
Explosion rocks Harvard medical building as suspects flee scene. Boston arson unit investigating intentional blast on fourth floor of Longwood medical campus. No injuries reported.