High point totals mean opportunity, and several key matchups stand out as potential fantasy goldmines in Week 10. Week 10 of the NFL season is already upon us, and the challenge of setting lineups and finding an edge in fantasy football only becomes greater than the week before.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime,

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Week 8's loss to the Houston Texans was a tough setback for the San Francisco 49ers, who had entered the game atop the NFC West standings. The defeat dropped San Francisco to the seventh seed in the conference playoff picture.

Sean McVay shared another update on Puka Nacua Monday, saying he's "optimistic" about the Rams WR heading into Week 10.

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.

Rams HC Sean McVay has an update on star WR Puka Nacua, who exited Sunday's blowout win vs. Saints with a chest/ribs injury

Matthew Stafford thrived once again for the Rams while the 49ers were ruthlessly efficient in Week 9 wins.

Matthew Stafford spoke candidly after drawing telling remarks from one of his Los Angeles Rams and defeating the New Orleans Saints.