In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly. The complex, a type of "protein chaperone" known as TRiC, helps ...

For decades, the standard explanation for autoimmune diseases like rheumatoid arthritis has rested on two pillars: inherited ...

Though many studies approach the developmental disorder Rett syndrome as a single condition arising from general loss of ...

In a new study published in Genes & Development, research led by Dr. Lila Allou at the MRC Laboratory of Medical Sciences (LMS) in London and Professor Stefan Mundlos at the Max Planck Institute for ...

Weill Cornell Medicine researchers have found that temporarily disabling a protein complex that organizes DNA into loops ...

The IQSEC2 gene encodes a guanine nucleotide exchange factor (Arf-GEF) that plays a critical role in synaptic regulation and neuronal development. Mutations in IQSEC2 have emerged as a significant ...

Schizophrenia is thought to affect 1 in 300 people, or about 0.32 percent of the global population, and treatment options are limited because of a poor understanding of the mechanisms underlying the ...

Two critical mutations appeared roughly 200,000 years ago in a gene linked to language, then swept through the population at roughly the same time anatomically modern humans began to dominate the ...

Millions of neurons branch throughout our bodies, keeping them in close communication with our brains. This peripheral ...

Psoriasis is a chronic inflammatory immune-mediated disease that causes patches of skin to become flaky or sore. The current cause of the condition is unknown and it is estimated that 125 million ...

Things are getting KRASy in Spanish science this week as two major papers debut new insight regarding the activity of the cancer-associated mutation KRAS. First, in an article published in Nature, a ...