Nature

Comprehensive data mining reveals RTK/RAS signaling pathway as a promoter of prostate cancer lineage plasticity through transcription factors and CNV

Prostate cancer lineage plasticity is a key driver in the transition to neuroendocrine prostate cancer (NEPC), and the RTK/RAS signaling pathway is a well-established cancer pathway. Nevertheless, the ...
ascopubs.org

Clinical outcomes of patients with RTK-RAS pathway alterations by treatment type: The MD Anderson Cancer Center IMPACT 2 study.

This is an ASCO Meeting Abstract from the 2026 ASCO Annual Meeting I. This abstract does not include a full text component.
Nature

Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling

The existence of oncogenes throughout healthy human tissues underscores decades of studies showing that cancer arises not only from the presence of an oncogene but also from improper regulation of ...
GEN

Oncogenic Signaling Shaped by a Golgi Trafficking Protein Pair

A new study in Science Signaling identifies a previously overlooked control point in receptor tyrosine kinase (RTK) signaling, one that operates not at the plasma membrane, but at the Golgi. The ...
ascopubs.org

Artificial intelligence–integrated profiling of JAK-STAT, MAPK, and RTK–RAS signaling alterations in chemotherapy-treated early-onset colorectal cancer among ...

Artificial intelligence comparison of Google MedGemma and ChatGPT-5 in expert-reviewed gastrointestinal and genitourinary oncology cases. This is an ASCO Meeting Abstract from the 2026 ASCO Annual ...