Aflac general counsel: Georgia lawmakers took a crucial step forward on sickle cell disease – but there’s more work to be done

A new Georgia law requires Medicaid to keep pace with sickle cell treatments. With World Sickle Cell Day on June 19, here's ...
News Medical

First U.S. trial uses non-viral CRISPR to correct sickle cell mutation

UCSF Benioff Children's Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell disease. The trial is the first in the U.S. to apply non-viral CRISPR-Cas9 ...

Early diagnosis of sickle cell anemia matters: Newborn screening and timely intervention

Sickle cell disease (SCD) is caused by a genetic mutation that affects haemoglobin. In people with SCD, abnormal haemoglobin ...
Nature

The quaternary structure origin of the fibrillation of sickle hemoglobin: a molecular dynamics study

Sickle cell disease is a genetic disease caused by a point mutation, where the 6th residue of β chains of hemoglobin (Hb) is replaced by valine. In an oxygen-scarce environment, the mutated Hb, sickle ...

Sickle Cell Anemia Awareness Day: Why Fighting Stigma Is As Important As Treatment

For people living with genetic disorders such as sickle cell disease and thalassemia, stigma can be as damaging as the ...
EurekAlert!

Novel gene therapy trial for sickle cell disease launches

UCSF Benioff Children's Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell disease. The trial is the first in the U.S. to apply non-viral CRISPR-Cas9 ...
Fred Hutch

Towards accessible gene therapy: in vivo base editing to cure Sickle Cell Disease

Sickle cell disease (SCD) is a genetic condition that affects more than 8 million people worldwide by altering the shape of oxygen-carrying red blood cells. Normally, red blood cells are shaped like ...
News Medical

Stiff red blood cells drive sickle cell disease severity

A new breakthrough study led by researchers at the University of Minnesota Twin Cities could explain why patients with the same genetic sickle cell mutation experience different levels of pain, organ ...
Acsh.org

Sickle Cell, Gene Therapy, and the Limits of Medical Triumph

Gene therapy has given sickle cell disease what medicine has long promised but rarely delivered: the possibility of a cure. Yet the slow uptake of Casgevy and Lyfgenia shows that even dazzling science ...
STAT

Sickle-cell disease associated with early onset of clonal hematopoiesis, a precancerous condition

The discovery, led by researchers at Dana-Farber, could pave the way for interventions to reduce the risk of blood cancers among people with sickle-cell disease. A large-scale genomic analysis, led by ...
Scientific American

A Global Initiative to Advance Sickle Cell Research Could Benefit Millions

This article is part of “Innovations In: Sickle Cell Disease,” an editorially independent special report that was produced with financial support from Vertex Pharmaceuticals. Sickle cell disease was ...