A key component of antiretroviral therapy (ART) for HIV patients is the nucleoside reverse transcriptase inhibitor (NRTI) is tenofovir. Recent reports of tenofovir toxicity in patients taking ART for ...
Correct DNA replication and cell cycle progression requires coordinated work of many enzymes and auxiliary proteins. Human PrimPol is a primase belonging to the archaeo-eukaryotic primase (AEP) ...
Binding of PrimPol to ICL lesions in DNA. PrimPol protein (red) is distributed between the nucleus (blue) and cytoplasm of osteosarcoma cells (left). In the presence of ICL lesions, PrimPol quickly ...
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