Background Fibrosis and tumour innervation are two features of the tumour microenvironment (TME) that contribute directly to ...
Background Clinicians use fibrosis in a liver biopsy to predict clinical outcomes of chronic liver disease. The performance of non-invasive tests has been evaluated against histological assessment of ...
I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...
Objective We performed a meta-analysis of observational studies to quantify the magnitude of the association between non-alcoholic fatty liver disease (NAFLD) and risk of extrahepatic cancers. Design ...
Background: Patients with irritable bowel syndrome (IBS) often feel they have some form of dietary intolerance and frequently try exclusion diets. Tests attempting to predict food sensitivity in IBS ...
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3 Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden 4 Department of Clinical and Experimental Medicine, Division of Inflammation ...
Afferent fibres convey sensory information from the upper gastrointestinal tract to the central nervous system but the nature of this information is different for vagal and spinal pathways. Vagal ...
Objective In the tumour microenvironment, critical drivers of immune escape include the oncogenic activity of the tumour cell-intrinsic osteopontin (OPN), the expression of programmed death ligand 1 ...
Background Despite the long-standing recommendations of high-protein diets for patients with cancer, the precise mechanisms of this dietary approach in benefiting tumour suppression and enhancing ...
Objective Microscopic colitis (MC) is a common cause of chronic diarrhoea, often with additional symptoms. No validated instruments exist to assess disease activity in MC, making it difficult to ...
a Inflammatory Bowel Disease Study Group, Royal Free Hospital School of Medicine, London, UK, b Gastroenterology Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK Dr R N Allan, Queen Elizabeth ...
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