Longitudinal QST phenotyping has revealed dynamic transitions across sensory subtypes. Patients may evolve from profiles ...
A new study shows that abstinent smokers experience heightened pain sensitivity linked to altered activity in specific brain ...
The Plausible Mechanism Pathway allows FDA drug approval without randomized trials, focusing on diseases with known biological causes. This pathway targets rare genetic diseases, emphasizing biologic ...
Abstract: This article provides an introduction to the theory of mechanism design and its application to engineering problems. Our aim is to provide the fundamental principles of mechanism design for ...
QST consistently reveals abnormalities in patients with OUD on OAT, underscoring altered central pain processing and potential utility for objective pain assessment in this population. Quantitative ...
BACKGROUND AND OBJECTIVES: According to the redefinition, acute pain is a somatic experience, with individual perception of physical or existential threat, comprising affective, cognitive and ...
I’ve been going down a gaming handheld rabbit hole for the last few years, spurred on by the Steam Deck back in 2022. While these PC handhelds definitely existed before that – usually with laptop ...
ABSTRACT: Objective: To investigate whether intraplantar injection of monosodium iodoacetate (MIA) in rats produces acute inflammatory pain and to explore whether the hyperalgesia is mediated by ...
Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain
Introduction: This study aims to investigate the interregional functional connectivity in chronic back pain patients with widespread hyperalgesia, patients with localized back pain, and pain-free ...
Intuitively, you think that everything that you stretch will pull back, but you wouldn’t expect a couple of pieces of plastic to win. Yet, researchers over at [AMOLF] have figured out a way to make a ...
Divers found the Antikythera mechanism in a shipwreck in 1900. Zde via Wikimedia Commons under CC BY-SA 4.0 More than a century ago, a group of sponge divers discovered a shipwreck near the Greek ...
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