gut.bmj

Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis

Correspondence to Dr Gyongyi Szabo, Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; gszabo1{at}bidmc.harvard.edu Objective Alcohol ...
gut.bmj

Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism

Background Fibrosis and tumour innervation are two features of the tumour microenvironment (TME) that contribute directly to the lethality of pancreatic ductal adenocarcinoma (PDAC), but their ...
gut.bmj

Early high-energy enteral nutrition in acute pancreatitis: overfeeding and respiratory risk in high-risk patients

I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...
gut.bmj

Gastritis staging in clinical practice: the OLGA staging system

Background: The available classifications of gastritis are inconsistently used, possibly because none provides immediate prognostic/therapeutic information to clinicians. As histology reporting of ...
gut.bmj

Landscape screening identifies the lactate-modifying enzyme AARS2 as a master regulator and therapeutic target in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC), one of the most prevalent cancers worldwide, has a high mortality owing to diagnostic challenges and therapeutic resistance. Lactate metabolism and protein ...
gut.bmj

The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

4 Department of Hepatogastroenterology, Hopital Claude Huriez, CHRU Lille, France Correspondence to: Professor J-F Colombel Department of Hepato-Gastroenterology, Hopital Claude Huriez, CHRU de Lille, ...
gut.bmj

Urgent versus early ERCP in mild-to-moderate acute cholangitis: a randomised controlled trial

Background The optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with mild-to-moderate acute cholangitis remains uncertain. Objective To compare the clinical outcomes ...
gut.bmj

Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome

Background Proteases and histamine, co-secreted by mast cells and bacteria, sensitise colonic nociceptors and contribute to irritable bowel syndrome (IBS) pain. Objective To determine whether ...
gut.bmj

MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk

Background Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and results from pathogenic germline variants affecting mismatch repair. The tissue microenvironment that ...
gut.bmj

12-HETE: a novel lipid mediator of CD8+ T cell dysfunction in MASH/HCC

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide and a tumour with robust molecular subtypes including hepatocyte-like, cholangiocyte-like and ...
gut.bmj

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes

1 Nerve-Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, The University of Adelaide and Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, ...