Objective To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). Design ...

Objective To provide the first international comparison of oesophageal and gastric cancer survival by stage at diagnosis and histological subtype across high-income countries with similar access to ...

The aim of this study was to establish the relative importance of risk factors for mortality after acute upper gastrointestinal haemorrhage, and to formulate a simple numerical scoring system that ...

Correspondence to Dr G Nicholas Verne, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112-2699, USA; gverne{at}tulane.edu Background More effective treatments are ...

Correspondence to Dr Richard C Pollok, Gastroenterology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; richard.pollok{at}nhs.net Objective Depression is a potential risk ...

Objective High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB). Although the immune-tolerant (IT) phase ...

Endoscopic submucosal dissection (ESD) enables en bloc resection for early gastrointestinal malignancies but is technically ...

Background Small intestinal bacterial overgrowth (SIBO) is a syndrome of absolute or relative elevation of the abundance of bacterial flora in the small intestine, which leads to a variety of ...

Objective To validate Lyon Consensus criteria for diagnosing gastro-oesophageal reflux disease (GORD) by reflux monitoring. Design Manual review of impedance-pH tracings from patients with proton pump ...

Background Small intestinal bacterial overgrowth (SIBO) is a clinical syndrome with abdominal complaints and malabsorption. Despite concerns over cure rates, recurrence, and antibiotic resistance, ...

Background Colonoscopy with pan-chromoendoscopy (CE) is superior to standard colonoscopy in detecting neoplasia in patients with IBD. Performing random biopsies in unsuspicious mucosa after CE remains ...

Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in ...